RELATIONSHIP BETWEEN SEASONAL PATTERNS OF PLATELET SEROTONIN UPTAKE AND H-3 IMIPRAMINE BINDING IN DEPRESSED-PATIENTS AND NORMAL CONTROLS

1. Significant seasonal variations were found in the velocity of serotonin (Vmax) uptake and the density of H-3-imipramine binding sites (Bmax) in blood plateles from normal controls. 2. Peak H-3-imipramine (H-3-IMI) binding was found in February whereas peak serotonin (5HT) uptake was found in June and these measures were not correlated in paired comparisons. 3. Both Vmax and Bmax values of depressed patients deviated from the normal seasonal pattern with lower uptake and binding in the patient group. 4. A comparison of Vmax and Bmax deviations from the normal patterns of uptake and binding revealed a significant correlation between these measures such that patients with low Vmax values were the same as those with low Bmax values. 5. The results support previous claims that the H-3-IMI binding site may be closely associated with, or identical to, a 5HT transport carrier. 6. A significant correlation between uptake and binding further suggests that a common defect may be responsible for observed decreases in Vmax and Bmax values of depressed patients.