CHARACTERIZATION OF A GLYCINE TO VALINE SUBSTITUTION AT AMINO-ACID POSITION-910 OF THE TRIPLE HELICAL REGION OF TYPE-III COLLAGEN IN A PATIENT WITH EHLERS-DANLOS SYNDROME TYPE-IV

被引:31
作者
RICHARDS, AJ
LLOYD, JC
WARD, PN
DEPAEPE, A
NARCISI, P
POPE, FM
机构
[1] INST ANIM HLTH,COMPTON RG16 0NN,BERKS,ENGLAND
[2] STATE UNIV GHENT,CTR MED GENET,B-9000 GHENT,BELGIUM
关键词
D O I
10.1136/jmg.28.7.458
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We have studied a patient with Ehlers-Danlos syndrome type IV. Protein mapping studies of her type III collagen had indicated that cyanogen bromide fragment 9 contained the site of the mutation. Here we describe the mapping of this region for a single base mutation using a chemical modification and cleavage technique. Sequence analysis of cDNA showed a G to T mutation resulting in the substitution of glycine 910 by valine. This was confirmed by allele specific oligonucleotide hybridisation to the proband's genomic DNA.
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页码:458 / 463
页数:6
相关论文
共 35 条
[1]   STRUCTURE OF CDNA CLONES CODING FOR THE ENTIRE PREPRO-ALPHA-1(III) CHAIN OF HUMAN TYPE-III PROCOLLAGEN - DIFFERENCES IN PROTEIN-STRUCTURE FROM TYPE-I PROCOLLAGEN AND CONSERVATION OF CODON PREFERENCES [J].
ALAKOKKO, L ;
KONTUSAARI, S ;
BALDWIN, CT ;
KUIVANIEMI, H ;
PROCKOP, DJ .
BIOCHEMICAL JOURNAL, 1989, 260 (02) :509-516
[2]   COLLAGEN DEFECTS IN LETHAL PERINATAL OSTEOGENESIS IMPERFECTA [J].
BATEMAN, JF ;
CHAN, D ;
MASCARA, T ;
ROGERS, JG ;
COLE, WG .
BIOCHEMICAL JOURNAL, 1986, 240 (03) :699-708
[3]  
BEIGHTON P, 1972, EHLERSDANLOS SYNDROM
[4]   THE NATIVE AND DENATURED STATES OF SOLUBLE COLLAGEN [J].
BOEDTKER, H ;
DOTY, P .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1956, 78 (17) :4267-4280
[5]   SUBTLE STRUCTURAL ALTERATIONS IN THE CHAINS OF TYPE-I PROCOLLAGEN PRODUCE OSTEOGENESIS IMPERFECTA TYPE-II [J].
BONADIO, J ;
BYERS, PH .
NATURE, 1985, 316 (6026) :363-366
[6]  
BYERS PH, 1981, LAB INVEST, V44, P336
[7]   INHERITED DISORDERS OF COLLAGEN GENE STRUCTURE AND EXPRESSION [J].
BYERS, PH .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1989, 34 (01) :72-80
[8]  
COLE WG, 1990, J BIOL CHEM, V265, P17070
[9]   REACTIVITY OF CYTOSINE AND THYMINE IN SINGLE-BASE-PAIR MISMATCHES WITH HYDROXYLAMINE AND OSMIUM-TETROXIDE AND ITS APPLICATION TO THE STUDY OF MUTATIONS [J].
COTTON, RGH ;
RODRIGUES, NR ;
CAMPBELL, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) :4397-4401
[10]  
DEPAEPE A, IN PRESS 6 P INT CLI