INSULIN-LIKE GROWTH FACTOR-I STIMULATES TRANSCRIPTION OF THE C-JUN PROTOONCOGENE IN BALB/C 3T3 CELLS

被引：19

作者：

CHIOU, ST

CHANG, WC

机构：

[1] NATL TAIWAN UNIV,INST BIOCHEM SCI,TAIPEI,TAIWAN

[2] ACAD SINICA,INST BIOL CHEM,TAIPEI 115,TAIWAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90513-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment of quiescent Balb c 3T3 cells with insulin-like growth factor I (IGF I) resulted in the stimulation of proto-oncogene c-jun transcription. Cells exposed to cycloheximide and IGF I together showed super-induction of c-jun transcripts. Nuclear run-off assay revealed that IGF I up-regulated c-jun only while cycloheximide was present. The stability of c-jun mRNA was markedly increased in the cells treated with IGF I. These results suggest that IGF I controls the expression of c-jun by increasing the transcriptional activity and stabilizing the existing transcripts. © 1992.

引用

页码：524 / 531

页数：8

共 33 条

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