COUPLING OF MICRODIALYSIS WITH CAPILLARY ELECTROPHORESIS - A NEW APPROACH TO THE STUDY OF DRUG TRANSFER BETWEEN 2 COMPARTMENTS OF THE BODY IN FREELY MOVING RATS

被引:33
作者
TELLEZ, S
FORGES, N
ROUSSIN, A
HERNANDEZ, L
机构
[1] EUROPHOR INSTRUMENTS,PARC TECHNOL CANAL,10 AVE EUROPE,F-31520 RAMONVILLE,FRANCE
[2] UNIV LOS ANDES,SCH MED,BEHAV PHYSIOL LAB,MERIDA,VENEZUELA
来源
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 581卷 / 02期
关键词
D O I
10.1016/0378-4347(92)80279-Y
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The feasibility of in vivo microdialysis and capillary electrophoresis for pharmacokinetic studies was tested. Microdialysis probes were inserted in the jugular vein and brain of rats. After an intraperitoneal injection of phenobarbital, microdialysis was performed in the brain and the blood simultaneously in each rat under freely moving conditions. Capillary electrophoresis with ultraviolet absorption was used to measure phenobarbital in blood and brain dialysates. The time course of phenobarbital in the blood and in the extracellular space of the brain was followed. The results demonstrated that microdialysis can be used for pharmacokinetic studies in freely moving animals. Capillary electrophoresis has the potential to improve the time resolution of microdialysis. Other advantages of microdialysis and capillary electrophoresis for pharmacokinetic studies are discussed.
引用
收藏
页码:257 / 266
页数:10
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