RESPONSE OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS TO GLUTAMATE-DECARBOXYLASE IN INSULIN-DEPENDENT DIABETES

被引：277

作者：

ATKINSON, MA

KAUFMAN, DL

CAMPBELL, L

GIBBS, KA

SHAH, SC

BU, DF

ERLANDER, MG

TOBIN, AJ

MACLAREN, NK

机构：

[1] UNIV CALIF LOS ANGELES,DEPT PSYCHIAT & BIOBEHAV SCI,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT BIOL,LOS ANGELES,CA 90024

[3] UNIV S FLORIDA,DEPT PEDIAT,TAMPA,FL 33620

来源：

LANCET | 1992年 / 339卷 / 8791期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0140-6736(92)91061-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-dependent diabetes is characterised by autoantibodies to several pancreatic-islet-cell antigens, including glutamate decarboxylase. We measured the proliferative responses to this antigen of peripheral-blood mononuclear cells from patients with newly diagnosed insulin-dependent diabetes, relatives of diabetic patients, and healthy controls. The likelihood of a positive response was substantially greater among the diabetic patients and relatives positive for islet-cell autoantibodies (ICA) than among subjects at low risk of diabetes (controls and ICA-negative relatives). Glutamate decarboxylase may have a pathogenetic role in insulin-dependent diabetes.

引用

收藏

页码：458 / 459

页数：2

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