MULTIRECOGNITION CAPABILITY OF E-SELECTIN IN A DYNAMIC FLOW SYSTEM, AS EVIDENCED BY DIFFERENTIAL-EFFECTS OF SIALIDASES AND ANTICARBOHYDRATE ANTIBODIES ON SELECTIN-MEDIATED CELL-ADHESION AT LOW VS HIGH WALL SHEAR-STRESS - A PRELIMINARY NOTE

被引：18

作者：

KOJIMA, N

HANDA, K

NEWMAN, W

HAKOMORI, S

机构：

[1] OTSUKA PHARMACEUT CO LTD,MARYLAND RES LABS,ROCKVILLE,MD 20850

[2] UNIV WASHINGTON,DEPT PATHOBIOL,SEATTLE,WA 98195

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)90272-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

E-selectin has a "multi-recognition" capability in terms of epitope binding specificity, depending on adhesion conditions (static vs. low- or high-shear stress dynamic systems). Specifically, (i) adhesion based on expression of α2→3 sialylated Lex (SLex) is prominent under static or low shear stress dynamic conditions; (ii) adhesion under high shear stress dynamic conditions does not depend on the known SLex species, but rather on Lex with an adjacent unidentified sialosyl substitution, which shows different susceptibility to sialidases and antibodies compared to known SLex. © 1992.

引用

页码：1686 / 1694

页数：9

共 15 条

[1]

BERG EL, 1991, J BIOL CHEM, V266, P14869

[2] ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE-1 - AN INDUCIBLE RECEPTOR FOR NEUTROPHILS RELATED TO COMPLEMENT REGULATORY PROTEINS AND LECTINS [J].