TRANSFORMATION OF MYELOMONOCYTIC CELLS BY THE AVIAN-MYELOBLASTOSIS VIRUS IS DETERMINED BY THE V-MYB ONCOGENE, NOT BY THE UNIQUE LONG TERMINAL REPEATS OF THE VIRUS

被引：6

作者：

ENGELKE, U ^{[1
]}

LIPSICK, JS ^{[1
]}

机构：

[1] STANFORD UNIV,SCH MED,DEPT PATHOL,STANFORD,CA 94305

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 04期

关键词：

D O I：

10.1128/JVI.68.4.2752-2755.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The avian myeloblastosis virus (AMV) induces acute monoblastic leukemia in chickens and transforms only myelomonocytic cells in vitro. The long terminal repeat (LTR) regulatory region of AMV is unique among the known classes of avian retrovirus LTRs. We demonstrate that the substitution of the AMV LTRs by Rous sarcoma virus LTRs did not alter the cell type specificity or the transforming ability of the virus.

引用

页码：2752 / 2755

页数：4

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