NERVE GROWTH-FACTOR PRESERVES BEHAVIORAL VISUAL-ACUITY IN MONOCULARLY DEPRIVED KITTENS

被引：22

作者：

FIORENTINI, A

BERARDI, N

MAFFEI, L

机构：

[1] UNIV NAPLES,DIPARTIMENTO FISIOL GEN & AMBIENTALE,NAPLES,ITALY

[2] SCUOLA NORMALE SUPER PISA,PISA,ITALY

来源：

VISUAL NEUROSCIENCE | 1995年 / 12卷 / 01期

关键词：

NERVE GROWTH FACTOR; VISUAL DEPRIVATION; BEHAVIORAL VISUAL ACUITY; CAT;

D O I：

10.1017/S0952523800007306

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent electrophysiological and anatomical experiments in rats and cats have shown that treatment with the neurotrophic factor-nerve growth factor (NGF)-prevents the effects of monocular deprivation (MD) at the level of visual cortex and lateral geniculate nucleus. We tested whether NGF treatment was effective in preventing MD effects on visual behavior of monocularly deprived kittens. Behavioral visual acuity was measured in kittens that had been monocularly deprived and treated intraventricularly with NGF for 2 weeks during the critical postnatal period. The detrimental effects of MD on behavioral visual acuity were found to be largely prevented by NGF treatment.

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页码：51 / 55

页数：5

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