SPECTROPHOTOMETRIC DETERMINATION OF CEFADROXIL AND METYROSINE IN DOSAGE FORMS

A simple and sensitive spectrophotometric method is described for the determination of cefadroxil and metyrosine in pure form and in pharmaceutical formulations. The method is based on reacting these drugs with 4-aminoantipyrine (AAP) in the presence of an all:aline oxidising agent. The coloured products were measured spectrophotometrically at 500 nm and 470 nm for cefadroxil and metyrosine, respectively. Beer's law was obeyed over the concentration range 1-28 and 2-44 mu g ml(-1) for cefadroxil monohydrate and metyrosine, respectively. The molar ratio in both cases was established and a proposal for the reaction pathway was suggested. The percentage recoveries obtained were in accordance with those given by the reference methods.