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STRUCTURE ELUCIDATION AND CHEMISTRY OF CATHARANTHUS ALKALOIDS .3. STRUCTURE OF LEUROSINE, AN ACTIVE ANTICANCER ALKALOID

被引：35
作者：
ABRAHAM, DJ
FARNSWORTH, NR
机构：
[1] Department of Pharmaceutical Chemistry, the Department of Pharmacognosy, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 06期
关键词：
Antitumor alkaloid—leurosine; Catharanthus alkaloids—leurosine structure; chemistry; IR spectrophotometry—structure; Mass spectroscopy structure; NMR spectroscopy—structure;
D O I：
10.1002/jps.2600580609
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Evidence for the structure of the antitumor alkaloid leurosine is presented, together with the explanations for the mass spectral fragmentation patterns observed. Nuclear magnetic resonance spectroscopic data support the proposal that leurosine contains an epoxide moiety, and is closely related to the other Catharanthus antitumor alkaloids vincaleukoblastine and leurosidine. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company
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页码：694 / +
页数：1
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