EFFECTS OF INOSITOL 1,4,5-TRISPHOSPHATE ON CALCIUM RELEASE FROM THE ENDOPLASMIC-RETICULUM AND GOLGI-APPARATUS IN MOUSE MAMMARY EPITHELIAL-CELLS - A COMPARISON DURING PREGNANCY AND LACTATION

被引：26

作者：

YOSHIMOTO, A

NAKANISHI, K

ANZAI, T

KOMINE, S

机构：

[1] Department of Biochemistry, School of Medicine Kyorin University, Mitaka, Tokyo

来源：

CELL BIOCHEMISTRY AND FUNCTION | 1990年 / 8卷 / 04期

关键词：

Ca[!sup]2+[!/sup; endoplasmic reticulum; Golgi apparatus; Inositol 1,4,5‐trisphosphate; mammary epithelial cell;

D O I：

10.1002/cbf.290080402

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been established that inositol 1,4,5‐trisphosphate(IP3) is responsible for the mobilization of calcium(Ca2+) from intracellular locations in a wide variety of tissues, and that this response triggers the stimulation of several hormones and neurotransmitters. However, these phenomena have yet to be examined in the mammary epithelium. Ca2+ uptake from the medium into the endoplasmic reticulum(ER) and Golgi apparatus in vitro in both pregnant and lactating mouse mammary epithelial cells was studied and a strong Ca2+ release from these organelles into the medium with the use of IP3 was shown. The Ca2+ uptake and its release due to IP3 was also usually greater during pregnancy than lactation. Copyright © 1990 John Wiley & Sons Ltd.

引用

页码：191 / 198

页数：8

共 28 条

[1] SEQUENTIAL PREPARATION OF RAT-LIVER MICROSOMAL AND GOLGI MEMBRANES [J].