A SINGLE AMINO-ACID SUBSTITUTION IN ENVELOPE PROTEIN-E OF TICK-BORNE ENCEPHALITIS-VIRUS LEADS TO ATTENUATION IN THE MOUSE MODEL

被引：122

作者：

HOLZMANN, H ^{[1
]}

HEINZ, FX ^{[1
]}

MANDL, CW ^{[1
]}

GUIRAKHOO, F ^{[1
]}

KUNZ, C ^{[1
]}

机构：

[1] UNIV VIENNA,INST VIROL,KINDERSPITALGASSE 15,A-1095 VIENNA,AUSTRIA

来源：

JOURNAL OF VIROLOGY | 1990年 / 64卷 / 10期

关键词：

D O I：

10.1128/JVI.64.10.5156-5159.1990

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

引用

页码：5156 / 5159

页数：4

共 31 条

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[4] EPITOPE MODEL OF TICK-BORNE ENCEPHALITIS-VIRUS ENVELOPE GLYCOPROTEIN-E - ANALYSIS OF STRUCTURAL-PROPERTIES, ROLE OF CARBOHYDRATE SIDE-CHAIN, AND CONFORMATIONAL-CHANGES OCCURRING AT ACIDIC PH [J].

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[5] COMPARISON OF THE VIRULENT ASIBI STRAIN OF YELLOW-FEVER VIRUS WITH THE 17D VACCINE STRAIN DERIVED FROM IT [J].

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[6] NUCLEOTIDE-SEQUENCE OF DENGUE-2 RNA AND COMPARISON OF THE ENCODED PROTEINS WITH THOSE OF OTHER FLAVIVIRUSES [J].

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[7] A TOPOLOGICAL AND FUNCTIONAL-MODEL OF EPITOPES ON THE STRUCTURAL GLYCOPROTEIN OF TICK-BORNE ENCEPHALITIS-VIRUS DEFINED BY MONOCLONAL-ANTIBODIES [J].

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[8] LOCATION OF IMMUNODOMINANT ANTIGENIC DETERMINANTS ON FRAGMENTS OF THE TICK-BORNE ENCEPHALITIS-VIRUS GLYCOPROTEIN - EVIDENCE FOR 2 DIFFERENT MECHANISMS BY WHICH ANTIBODIES MEDIATE NEUTRALIZATION AND HEMAGGLUTINATION INHIBITION [J].

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[9] A MODEL STUDY OF THE USE OF MONOCLONAL-ANTIBODIES IN CAPTURE ENZYME IMMUNOASSAYS FOR ANTIGEN QUANTIFICATION EXPLOITING THE EPITOPE MAP OF TICK-BORNE ENCEPHALITIS-VIRUS [J].

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[10] CHARACTERIZATION OF ANTIGENIC VARIANTS OF TICK-BORNE ENCEPHALITIS-VIRUS SELECTED WITH NEUTRALIZING MONOCLONAL-ANTIBODIES [J].

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GUIRAKHOO, F ;

HEINZ, FX ;

KUNZ, C .

JOURNAL OF GENERAL VIROLOGY, 1989, 70 :219-222

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