DIMINUTION BY VESICULAR STOMATITIS-VIRUS OF ACUTE GRAFT VS HOST MORTALITY IN MICE

被引：4

作者：

UMETSU, DT ^{[1
]}

ROMANO, TJ ^{[1
]}

BLOOM, BR ^{[1
]}

THORBECKE, GJ ^{[1
]}

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL,BRONX,NY 10461

来源：

CELLULAR IMMUNOLOGY | 1979年 / 46卷 / 02期

关键词：

D O I：

10.1016/0008-8749(79)90429-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Preincubation of parental spleen cells with vesicular stomatitis virus (VSV) in vitro reduces their subsequent ability to cause lethal GVH disease in irradiated F1 hybrid recipients. Antibody to VSV is needed to protect the irradiated mice against the virus. Protection is afforded even to the acute GVH induced by spleen cells presensitized to the other parent. No reduction of the late-occurring GVH mortality is obtained with VSV, even though this late GVH is mediated by T cells as it is completely abolished by pretreatment of BM with anti-Thy 1.2 + C. The results suggest that the known ability of VSV to replicate in activated T cells may be used selectively to inhibit certain unwanted immune reactions in vivo. © 1979.

引用

页码：416 / 421

页数：6

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