BIOCONCENTRATION FACTORS AND LIPID SOLUBILITY

被引：30

作者：

BANERJEE, S ^{[1
]}

BAUGHMAN, GL ^{[1
]}

机构：

[1] US EPA,ENVIRONM RES LAB,ATHENS,GA 30613

来源：

ENVIRONMENTAL SCIENCE & TECHNOLOGY | 1991年 / 25卷 / 03期

关键词：

D O I：

10.1021/es00015a024

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The log-log relationship between bioconcentration and hydrophobicity breaks down for several medium and high molecular weight solutes that bioconcentrate either to a small extent or not at all. Much of the failure is attributed to the relatively low solubility of these compounds in lipid. Inclusion of a term in octanol solubility (in place of lipid solubility, which is generally unavailable) considerably improves the quality of the relationship (r = 0.95). It is speculated that the octanol solubility term compensates for the relatively low solubility of large compounds in lipid.

引用

收藏

页码：536 / 539

页数：4

相关论文

共 29 条

[1] THE LIMITS OF BIOACCUMULATION OF ORGANIC PIGMENTS IN FISH - THEIR RELATION TO THE PARTITION-COEFFICIENT AND THE SOLUBILITY IN WATER AND OCTANOL [J].

ANLIKER, R ;

MOSER, P .

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 1987, 13 (01) :43-52

[2]

[Anonymous], 1987, PROPERTIES GASES LIQ

[3] USING UNIFAC TO CALCULATE AQUEOUS SOLUBILITIES [J].

ARBUCKLE, WB .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1986, 20 (10) :1060-1064

[4] IMPROVED ESTIMATION OF SOLUBILITY AND PARTITIONING THROUGH CORRECTION OF UNIFAC-DERIVED ACTIVITY-COEFFICIENTS [J].

BANERJEE, S ;

HOWARD, PH .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1988, 22 (07) :839-841

[5] BIOACCUMULATION OF SUPER-LIPOPHILIC CHEMICALS IN FISH [J].

BRUGGEMAN, WA ;

OPPERHUIZEN, A ;

WIJBENGA, A ;

HUTZINGER, O .

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, 1984, 7 (03) :173-189

[6]

GOBAS FAP, 1987, QSAR ENV TOXICOLOGY, V2

[7] A NOVEL METHOD FOR MEASURING MEMBRANE-WATER PARTITION-COEFFICIENTS OF HYDROPHOBIC ORGANIC-CHEMICALS - COMPARISON WITH 1-OCTANOL-WATER PARTITIONING [J].

GOBAS, FAPC ;

LAHITTETE, JM ;

GAROFALO, G ;

WAN, YS ;

MACKAY, D .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1988, 77 (03) :265-272

[8] BIOCONCENTRATION OF POLYBROMINATED BENZENES AND BIPHENYLS AND RELATED SUPERHYDROPHOBIC CHEMICALS IN FISH - ROLE OF BIOAVAILABILITY AND ELIMINATION INTO THE FECES [J].

GOBAS, FAPC ;

CLARK, KE ;

SHIU, WY ;

MACKAY, D .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 1989, 8 (03) :231-245

[9]

Hildebrand J. H., 1964, SOLUBILITY NONELECTR, V3rd

[10] AQUEOUS SOLUBILITY AND NORMAL-OCTANOL WATER PARTITION-COEFFICIENT CORRELATIONS [J].

ISNARD, P ;

LAMBERT, S .

CHEMOSPHERE, 1989, 18 (9-10) :1837-1853