INTERCONNECTION BETWEEN THYROID-HORMONE SIGNALING PATHWAYS AND PARVOVIRUS CYTOTOXIC FUNCTIONS

被引：31

作者：

VANACKER, JM ^{[1
]}

LAUDET, V ^{[1
]}

ADELMANT, G ^{[1
]}

STEHELIN, D ^{[1
]}

ROMMELAERE, J ^{[1
]}

机构：

[1] INST PASTEUR,UNITE ONCOL MOLEC,CNRS,URA 1160,F-75724 PARIS 15,FRANCE

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 12期

关键词：

D O I：

10.1128/JVI.67.12.7668-7672.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nonstructural (NS) proteins of autonomous parvoviruses can repress expression driven by heterologous promoters, an activity which thus far has not been separated from their cytotoxic effects. It is shown here that, in transient transfection assays, the NS-1 protein of the parvovirus minute virus of mice (MVMp) activates the promoter of the human c-erbA1 gene, encoding the thyroid hormone (T3) receptor alpha. The endogenous c-erbA1 promoter is also a target for induction upon MVMp infection. Moreover, T3 was found to up-modulate the level of cell sensitivity to parvovirus attack. These data suggest an interconnection between T3 signalling and NS cytotoxic pathways.

引用

页码：7668 / 7672

页数：5

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