DIFFERENTIAL-EFFECTS OF SHORT-TERM OR PROLONGED COCAINE EXPOSURE ON PERIPHERAL-BLOOD CELLS IN MICE

被引：16

作者：

DIFRANCESCO, P ^{[1
]}

FALCHETTI, R ^{[1
]}

GAZIANO, R ^{[1
]}

LANZILLI, G ^{[1
]}

BELOGI, L ^{[1
]}

RAVAGNAN, G ^{[1
]}

GARACI, E ^{[1
]}

机构：

[1] CNR,INST EXPTL MED,ROME,ITALY

来源：

LIFE SCIENCES | 1994年 / 54卷 / 25期

关键词：

COCAINE; IMMUNE SYSTEM; NEUROIMMUNOMODULATION;

D O I：

10.1016/0024-3205(94)90136-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of cocaine on the number of murine peripheral blood cells and on phenotypic expression of lymphocyte subsets were examined using different regimens of drug exposure. Cocaine administered to mice for 7 consecutive days at 1 and 10 mg/kg/day reduced the absolute number of circulating white blood cells and the relative number of cells stained as lymphocytes, polymorphonuclear cells and monocytes. Cocaine did not modify the relative proportion between lymphocytes, polymorphonuclear cells and monocytes, Parallely, there were no changes in the percentage of circulating CD4+ and CD8+ lymphocytes, while the number of natural killer cells increased. In sharp contrast, we didn't observe any significant change in peripheral blood cells after 30 days of consecutive drug administrations.

引用

页码：2015 / 2020

页数：6

共 25 条

[1] PSYCHONEUROIMMUNOLOGY - CONDITIONING AND STRESS [J].