SYNTHESIS OF A NEW-GENERATION REVERSE-TRANSCRIPTASE INHIBITOR VIA THE BCL3/GACL3-INDUCED CONDENSATION OF ANILINES WITH NITRILES (SUGASAWA REACTION)

被引:24
作者
HOUPIS, IN
MOLINA, A
DOUGLAS, AW
XAVIER, L
LYNCH, J
VOLANTE, RP
REIDER, PJ
机构
[1] Merck Research Laboratories, Process Research, Rahway, NJ 07065, P.O. Box 2000
关键词
D O I
10.1016/0040-4039(94)85011-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.
引用
收藏
页码:6811 / 6814
页数:4
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