IN-VITRO ANTISPASMODIC ACTIVITY OF PERACETYLATED PENSTEMONOSIDE, AUCUBIN AND CATALPOL

被引：31

作者：

DEURBINA, AVO

MARTIN, ML

FERNANDEZ, B

SANROMAN, L

CUBILLO, L

机构：

[1] UNIV SALAMANCA,FAC FARM,DEPT FISIOL & FARMACOL,FARMACOGNOSIA & FARMACODINAMIA LAB,E-37007 SALAMANCA,SPAIN

[2] UNIV SALAMANCA,FAC QUIM,DEPT QUIM ORGAN,E-37008 SALAMANCA,SPAIN

来源：

PLANTA MEDICA | 1994年 / 60卷 / 06期

关键词：

PENSTEMONOSIDE; AUCUBIN; CATALPOL; IRIDOIDS; PARENTUCELLIA LATIFOLIA (L) CARUEL; SCROPHULARIACEAE; ANTISPASMODIC ACTIVITY;

D O I：

10.1055/s-2006-959561

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In vitro, the peracetates of penstemonoside, aucubin and catalpol, iridoids isolated from Parentucellia latifolia, antagonize the uterine muscular contractions induced by acetylcholine and calcium, in a similar way to papaverine. The antagonism is non-competitive against acetylcholine (pD(2)' values: 5.60 for the peracetates of penstemonoside, 5.74 for aucubin, 5.59 for catalpol, and 5.32 for papaverine) and competitive against calcium (pA(2) values: 6.60 for the peracetates of penstemonoside, 6.34 for aucubin, 6.48 for catalpol, and 6.23 for papaverine).

引用

页码：512 / 515

页数：4

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