LOCALIZATION OF A PUTATIVE TUMOR-SUPPRESSOR GENE BY USING HOMOZYGOUS DELETIONS IN MELANOMAS

被引：76

作者：

WEAVERFELDHAUS, J

GRUIS, NA

NEUHAUSEN, S

LEPASLIER, D

STOCKERT, E

SKOLNICK, MH

KAMB, A

机构：

[1] MYRIAD GENET INC,SALT LAKE CITY,UT 84108

[2] LEIDEN UNIV,CTR GENET MED,DEPT HUMAN GENET,2300 RA LEIDEN,NETHERLANDS

[3] UNIV LEIDEN HOSP,DEPT DERMATOL,2300 RA LEIDEN,NETHERLANDS

[4] UNIV UTAH,CTR MED,DEPT MED INFORMAT,SALT LAKE CITY,UT 84108

[5] CTR ETUD POLYMORPHISME HUMAIN,FDN JEAN DAUSSET,F-75010 PARIS,FRANCE

[6] MEM SLOAN KETTERING CANC CTR,LUDWIG INST CANC RES,NEW YORK,NY 10021

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 16期

关键词：

D O I：

10.1073/pnas.91.16.7563

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have been isolated. A set of sequence-tagged sites in this region has been developed. By using these markers and others previously reported, the 9p21 region has been studied by physical mapping in 84 melanoma cell lines. A putative tumor suppressor gene, perhaps MLM itself, has been localized to a region of less than 40 kb that lies proximal (centromeric) to the alpha-interferon gene cluster.

引用

页码：7563 / 7567

页数：5

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