STUDIES ON METABOLISM OF C19 STEROIDS IN RAT LIVER .5. 18-HYDROXYLATION OF 17BETA-HYDROXY-C19 STEROIDS IN RAT LIVER MICROSOMES

被引：22

作者：

GUSTAFSSON, JA

LISBOA, BP

机构：

[1] Department of Chemistry, Karolinska Institutet, Stockholm

来源：

STEROIDS | 1969年 / 14卷 / 06期

关键词：

D O I：

10.1016/S0039-128X(69)80074-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After incubation of testosterone, 18-hydroxytestosterone and 5α-dihydrotestosterone with rat liver microsomes 17β,18-dihydroxy-5α-androstan-3-one, 5α-androstane-3α,17β,18-triol and 5α-androstane-3β,17β,18-triol have been isolated and characterized by thin-layer and gas-liquid chromatography and by gas chromatography-mass spectrometry. Furthermore, after incubation of 5α-dihydrotestosterone two androstanetetrols were isolated, the mass spectrometric characteristics of which indicate the presence of an 18-hydroxyl group. © 1969.

引用

页码：659 / +

页数：1

共 30 条

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