INHIBITION OF 5-HYDROXYTRYPTAMINE REUPTAKE BY AMITRIPTYLINE AND ZIMELIDINE AND ITS RELATIONSHIP TO THEIR THERAPEUTIC ACTION

被引：48

作者：

COPPEN, A

RAO, VAR

SWADE, C

WOOD, K

机构：

[1] MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, KT19 8PB, Surrey

来源：

PSYCHOPHARMACOLOGY | 1979年 / 63卷 / 02期

关键词：

5-Hydroxytryptamine; Amitriptyline; Depressive illness; Platelet; Zimelidine;

D O I：

10.1007/BF00429689

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amitriptyline and zimelidine significantly reduce the uptake of 5-HT into the blood platelets of depressive patients. The degree of inhibition is significantly correlated with the plasma drug level of amitriptyline. No significant relationship could be detected between the degree of inhibition of uptake and therapeutic outcome. The accepted mode of action of tricyclic antidepressant drugs and the deficiency hypotheses of affective disorders are discussed. © 1979 Springer-Verlag.

引用

页码：125 / 129

页数：5

共 22 条

[1] CONTRIBUTION OF DRUG RESEARCH TO INVESTIGATING NATURE OF ENDOGENOUS-DEPRESSION [J].