CENTRAL-NERVOUS-SYSTEM METHYL-GROUP METABOLISM IN CHILDREN WITH NEUROLOGICAL COMPLICATIONS OF HIV-INFECTION

被引：62

作者：

SURTEES, R

HYLAND, K

SMITH, I

机构：

[1] Department of Child Health, Institute of Child Health, London, WC1N 1 EH

来源：

LANCET | 1990年 / 335卷 / 8690期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0140-6736(90)90409-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To assess methyl-group metabolism in the central nervous system in infection with human immunodeficiency virus (HIV), levels of 5-methyltetrahydrofolate, methionine, and S-adenosylmethionine were measured by high-performance liquid chromatography in cerebrospinal fluid (CSF) from six children with congenital HIV infection and neurological complications. Total neopterins were also measured, as a marker of macrophage activation. In all six children concentrations of one or more methyl-group carriers were lower than those in a reference population of children, and all of the five in whom CSF neopterins were measured had higher than normal levels. Defective methylation may play a part in the neurological damage caused by HIV infection. © 1990.

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页码：619 / 621

页数：3

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