FIBRONECTIN DISTRIBUTION IN NORMAL AND MALIGNANT UROTHELIUM

被引：14

作者：

GROSSMAN, HB ^{[1
]}

LIEBERT, M ^{[1
]}

WEDEMEYER, G ^{[1
]}

WILSON, G ^{[1
]}

FLINT, A ^{[1
]}

机构：

[1] UNIV MICHIGAN,MED CTR,DEPT PATHOL,ANN ARBOR,MI 48109

来源：

JOURNAL OF UROLOGY | 1990年 / 143卷 / 02期

关键词：

D O I：

10.1016/S0022-5347(17)39977-9

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Fibronectin is a glycoprotein that mediates the attachment of BCG to the murine bladder. To assess the potential role of fibronectin on bladder cancer cells as a specific substrate for BCG binding in man, a semi-quantitative method was employed to evaluate the presence of fibronectin on normal urothelium and blader cancer. Monoclonal anti-fibronectin binding to normal and malignant urothelial tissues was evaluated by an immunoperoxidase assay. Human tumor cell lines were evaluated with mixed hemadsorption and immunoperoxidase assays. In both systems, immunoreactive fibronectin had low expression on unfixed normal and malignant urothelium. With fixation, immunoreactive fibronectin decreased on supporting stroma and increased in normal and malignant urothelium. Fibronectin distribution did not show tumor specificity either with fixed or unfixed specimens.

引用

页码：418 / 420

页数：3

共 18 条

[1]

GROSSMAN HB, 1983, SURG FORUM, V34, P672

[2] HYBRIDOMA ANTIBODIES REACTIVE WITH HUMAN BLADDER-CARCINOMA CELL-SURFACE ANTIGENS [J].