AMINO-TERMINAL SEQUENCES OF A NOVEL HEPARIN-BINDING PROTEIN FROM HUMAN, BOVINE, RAT, AND CHICK BRAIN - HIGH INTERSPECIES HOMOLOGY

被引:28
作者
HUBER, D [1 ]
GAUTSCHISOVA, P [1 ]
BOHLEN, P [1 ]
机构
[1] UNIV ZURICH, INST BIOCHEM, CH-8057 ZURICH, SWITZERLAND
关键词
bovine; brain; chicken; Heparin-binding protein; human; N-terminal sequence; rat; sequence homology;
D O I
10.1007/BF00969930
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recently, the partial structural characterization of a novel bovine brain protein was reported (1). Because of its mitogenic activity for vascular endothelial cells and its ability to strongly bind heparin it was termed heparin-binding brain mitogen (HBBM). Although HBBM shares these properties with members of the fibroblast growth factor (FGF) family of growth factors, its aminoterminal sequence is not homologous to that of the FGFs. Now, we report the isolation and partial structural characterization of HBBMs from human, rat and chick brain. Proteins were isolated by tissue extraction at pH 4.5, ammonium sulfate precipitation, cation exchange chromatography, heparin-Sepharose affinity chromatography and reverse-phase HPLC. The amino-terminal sequences of the HBBMs from human, bovine and rat brain are identical, whereas that of chick HBBM reveals a single amino acid substitution. The high sequence homology among the HBBMs from different species suggests an important biological role of the protein. © 1990 Plenum Publishing Corporation.
引用
收藏
页码:435 / 439
页数:5
相关论文
共 20 条
[1]   ACIDIC FIBROBLAST GROWTH-FACTOR (FGF) FROM BOVINE BRAIN - AMINO-TERMINAL SEQUENCE AND COMPARISON WITH BASIC FGF [J].
BOHLEN, P ;
ESCH, F ;
BAIRD, A ;
GOSPODAROWICZ, D .
EMBO JOURNAL, 1985, 4 (08) :1951-1956
[2]   ISOLATION AND PARTIAL MOLECULAR CHARACTERIZATION OF PITUITARY FIBROBLAST GROWTH-FACTOR [J].
BOHLEN, P ;
BAIRD, A ;
ESCH, F ;
LING, N ;
GOSPODAROWICZ, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (17) :5364-5368
[3]  
Bohlen P., 1988, J CELL BIOCH SA, V12A, P221
[4]  
Bohlen P., 1989, MACROPHAGE DERIVED C, V1, P204
[5]   AN ONCOGENE ISOLATED BY TRANSFECTION OF KAPOSIS-SARCOMA DNA ENCODES A GROWTH-FACTOR THAT IS A MEMBER OF THE FGF FAMILY [J].
BOVI, PD ;
CURATOLA, AM ;
KERN, FG ;
GRECO, A ;
ITTMANN, M ;
BASILICO, C .
CELL, 1987, 50 (05) :729-737
[6]   POTENTIAL ONCOGENE PRODUCT RELATED TO GROWTH-FACTORS [J].
DICKSON, C ;
PETERS, G .
NATURE, 1987, 326 (6116) :833-833
[7]   PRIMARY STRUCTURE OF BOVINE PITUITARY BASIC FIBROBLAST GROWTH-FACTOR (FGF) AND COMPARISON WITH THE AMINO-TERMINAL SEQUENCE OF BOVINE BRAIN ACIDIC FGF [J].
ESCH, F ;
BAIRD, A ;
LING, N ;
UENO, N ;
HILL, F ;
DENOROY, L ;
KLEPPER, R ;
GOSPODAROWICZ, D ;
BOHLEN, P ;
GUILLEMIN, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (19) :6507-6511
[8]   PITUITARY FOLLICULAR CELLS SECRETE A NOVEL HEPARIN-BINDING GROWTH-FACTOR SPECIFIC FOR VASCULAR ENDOTHELIAL-CELLS [J].
FERRARA, N ;
HENZEL, WJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 161 (02) :851-858
[9]   CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF A TRUNCATED FORM OF ACIDIC FIBROBLAST GROWTH-FACTOR FROM BOVINE BRAIN [J].
GAUTSCHI, P ;
FRATERSCHROEDER, M ;
MULLER, T ;
BOHLEN, P .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 160 (02) :357-361
[10]   PARTIAL MOLECULAR CHARACTERIZATION OF ENDOTHELIAL-CELL MITOGENS FROM HUMAN-BRAIN - ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS [J].
GAUTSCHI, P ;
FRATERSCHRODER, M ;
BOHLEN, P .
FEBS LETTERS, 1986, 204 (02) :203-207