IMMUNOLOGICAL REGULATION IN PREGNANCY

被引：44

作者：

STITES, DP

PAVIA, CS

CLEMENS, LE

KUHN, RW

SIITERI, PK

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT OBSTET GYNECOL & REPROD SCI,SAN FRANCISCO,CA 94143

[4] UNIV CALIF SAN FRANCISCO,INST REPROD ENDOCRINOL,SAN FRANCISCO,CA 94143

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 11期

关键词：

D O I：

10.1002/art.1780221119

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Theories to explain the failure of rejection of the fetus by the mother during pregnancy include immunologic privilege of the uterus as a graft site, lack of transplantation antigen expression on the trophoblast, weakening of maternal cellular immunity during pregnancy, and separation of maternal and fetal circulations. Evidence for and against each of these theories is discussed. Local concentration of a variety of hormones, including human chorionic gonadotropin (HCG), sex steroids, alpha‐fetoprotein, and immunoglobulins, could provide a blocking mechanism to prevent maternal cellular immune attack. Possibly, progesterone, antibodies, and immune complexes are important in protecting the placenta and ultimately the fetus from rejection. Elucidation of regulatory mechanisms in pregnancy may be applicable to other problems in immunology. Copyright © 1979 American College of Rheumatology

引用

页码：1300 / 1307

页数：8

共 66 条

[1] HUMAN CHORIONIC GONADOTROPIN - ITS POSSIBLE ROLE IN MATERNAL LYMPHOCYTE SUPPRESSION [J].