INCREASED AMMONIAGENESIS AS A DETERMINANT OF PROGRESSIVE RENAL INJURY

被引：98

作者：

NATH, KA ^{[1
]}

HOSTETTER, MK ^{[1
]}

HOSTETTER, TH ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT MED & PEDIAT,MINNEAPOLIS,MN 55455

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1991年 / 17卷 / 06期

关键词：

AMMONIA; TUBULOINTERSTITIAL INJURY; GROWTH; OXIDANTS;

D O I：

10.1016/S0272-6386(12)80344-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Loss of renal mass evokes increased ammoniagenesis in surviving nephrons, which in turn enables net acid excretion by the kidney. However, this compensatory increase in ammonia production in surviving nephrons triggers the alternative complement pathway, thereby instigating progressive tubulointerstitial injury. Ammonia has recently been identified as a stimulus to renal growth. Enhanced renal growth may serve as a forerunner for renal injury. The growth-promoting properties of ammonia may provide another mechanism through which augmented ammoniagenesis may underlie the enhancement of renal growth and injury observed in such models as the remnant kidney, hypokalemic nephropathy, high protein feeding, experimental diabetes nephropathy, and dietary deficiency of antioxidants. © 1991, National Kidney Foundation, Inc.. All rights reserved.

引用

页码：654 / 657

页数：4

共 20 条

[1] EFFECT OF REDUCED RENAL MASS ON AMMONIUM HANDLING AND NET ACID FORMATION BY THE SUPERFICIAL AND JUXTAMEDULLARY NEPHRON OF THE RAT - EVIDENCE FOR IMPAIRED REENTRAPMENT RATHER THAN DECREASED PRODUCTION OF AMMONIUM IN THE ACIDOSIS OF UREMIA [J].