THE EFFICACY OF METHOTREXATE IN PSORIASIS - A REVIEW OF 40 CASES

被引：46

作者：

COLLINS, P

ROGERS, S

机构：

[1] ST VINCENTS HOSP,DUBLIN 4,IRELAND

[2] CITY DUBLIN SKIN & CANC HOSP,DUBLIN 2,IRELAND

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 1992年 / 17卷 / 04期

关键词：

D O I：

10.1111/j.1365-2230.1992.tb02161.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Forty patients with psoriasis treated with methotrexate (MTX) are reviewed. MTX was particularly effective in controlling erythrodermic and generalized pustular psoriasis. The treatment was discontinued in seven patients due to nausea in two and because of abnormal laboratory tests in five. Two patients developed toxic epidermal necrolysis (TEN) and died. Patients under 60 years of age had a liver biopsy before treatment and repeat biopsy after each cumulative MTX dose of 1500 mg. We consider that MTX is the drug of choice for treating difficult psoriasis.

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页码：257 / 260

页数：4

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