INTERLEUKIN-1-BETA STIMULATES FIBROBLAST ELASTASE ACTIVITY

被引：25

作者：

CROUTE, F

DELAPORTE, E

BONNEFOY, JY

FERTIN, C

THIVOLET, J

NICOLAS, JF

机构：

[1] HOP EDOUARD HERRIOT,DERMATOL CLIN,INSERM,U209,F-69437 LYONS 03,FRANCE

[2] GLAXO IMB,GENEVA,SWITZERLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1991年 / 124卷 / 06期

关键词：

D O I：

10.1111/j.1365-2133.1991.tb04946.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report the stimulation of elastase activity of human skin fibroblasts by interleukin-1-beta (IL-1). Elastase activity was determined by the hydrolysis of the synthetic substrate succinoyl trialanine paranitroanilide (Suc(Ala3)NA). Recombinant human IL-1-beta induced a concentration-dependent increase in the elastase activity of fibroblasts. The supernatants of keratinocyte cultures that contained IL-1/ETAF showed similar stimulatory activity.

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收藏

页码：538 / 541

页数：4

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