ABSOLUTE-CONFIGURATION OF EPI-RHODODENDRIN AND (-)-RHODODENDROL [=(-)-BETULIGENOL] AND X-RAY CRYSTAL AND MOLECULAR-STRUCTURE OF RHODODENDRIN [= BETULOSIDE], A HEPATOPROTECTIVE CONSTITUENT OF TAXUS-BACCATA

被引：33

作者：

PARMAR, VS

VARDHAN, A

TANEJA, P

SINHA, R

PATNAIK, GK

TRIPATHI, SC

BOLL, PM

LARSEN, S

机构：

[1] CENT DRUG RES INST,DEPT PHARMACOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

[2] UNIV COPENHAGEN,DEPT CHEM,DK-2100 COPENHAGEN,DENMARK

[3] ODENSE UNIV,DEPT CHEM,DK-5230 ODENSE,DENMARK

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 11期

关键词：

D O I：

10.1039/p19910002687

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhododendrin (= betuloside) has been isolated from the leaves of Taxus baccata L. From its X-ray diffraction studies, the absolute configuration at the chiral centre in the aglucone portion has been found to be R. These results establish the stereochemical assignments to different samples of this glucoside isolated from different plants. Our sample of rhododendrin exhibited hepatoprotective activity against two hepatotoxins in rats.

引用

页码：2687 / 2690

页数：4

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