A PROSPECTIVE-STUDY OF TOBACCO USE AND MULTIPLE-MYELOMA - EVIDENCE AGAINST AN ASSOCIATION

被引：25

作者：

HEINEMAN, EF

ZAHM, SH

MCLAUGHLIN, JK

VAUGHT, JB

HRUBEC, Z

机构：

来源：

CANCER CAUSES & CONTROL | 1992年 / 3卷 / 01期

关键词：

CIGARETTES; MULTIPLE MYELOMA; TOBACCO; UNITED-STATES; VETERANS;

D O I：

10.1007/BF00051909

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The relationship between the use of cigarettes and other tobacco products and the risk of multiple myeloma was examined in a cohort of nearly 250,000 American veterans followed prospectively for 26 years. Compared with men who had never used tobacco, the risk of death from myeloma was not increased among current (relative risk [RR] = 0.9, 95 percent confidence interval [CI] = 0.8 - 1.2) or former (RR = 1.0, CI = 0.8 -1.3) cigarette smokers, nor among users of chewing tobacco or snuff (RR = 1.0, CI = 0.4 -2.3). Risk was only slightly and nonsignificantly increased among pipe or cigar smokers (RR = 1.2, CI = 0.9 -1.5). There was no indication of increasing risk with amount of tobacco used or earlier age at first use. With over 90 percent power to detect a 30 percent increased risk of this tumor occurring among current cigarette smokers, this study provides the strongest evidence to date against an association of cigarette smoking with multiple myeloma.

引用

页码：31 / 36

页数：6

共 26 条

[1]

Ries, LA H, Cancer Statistics Review 1973–1987, (1990)

[2]

Riedel D.A., Pottern L.M., Blattner W.A., Canellos G.P., The epidemiology of multiple myeloma, Neoplastic Disease of the Blood, pp. 347-72, (1991)

[3]

Mills P.K., Newell G.R., Beeson W.L., Fraser G.E., Phillips R.L., History of cigarette smoking and risk of leukemia and myeloma: results from the Adventist Health Study, JNCI, 82, pp. 1832-6, (1990)

[4]

Heath C.W., Cigarette smoking and hematopoietic cancer, JNCI, 82, pp. 1800-1, (1990)

[5]

Brownson R.C., Cigarette smoking and risk of myeloma, JNCI, 83, pp. 1036-7, (1991)

[6]

Boffetta P., Stellman S.D., Garfinkel L., A case-control study of multiple myeloma nested in the American Cancer Society prospective study, Int J Cancer, 43, pp. 443-9, (1989)

[7]

Flodin U., Fredriksson M., Persson B., Multiple myeloma and engine exhausts, fresh wood, and creosote: a casereferent study, Am J Indust Med, 12, pp. 519-29, (1987)

[8]

Linet, Harlow S.D., McLaughlin J.K., A case-control study of multiple myeloma in whites: chronic antigenic stimulation, occupation, and drug use, Cancer Res, 47, pp. 2978-81, (1987)

[9]

Gallagher R.P., Spinelli J.J., Elwood J.M., Skippen D.H., Allergies and agricultural exposure as risk factors for multiple myeloma, Br J Cancer, 48, pp. 853-7, (1983)

[10]

Garfinkel L., Cancer mortality in nonsmokers: prospective study by the American Cancer Society, JNCI, 65, pp. 1169-73, (1980)

← 1 2 3 →