CHOLINESTERASES IN THE AMYLOID ANGIOPATHY OF ALZHEIMERS-DISEASE

被引：27

作者：

MESULAM, M

CARSON, K

PRICE, B

GEULA, C

机构：

[1] BETH ISRAEL HOSP,DIV NEUROSCI & BEHAV NEUROL,BULLARD & DENNY BROWN LAB,BOSTON,MA 02215

[2] OLD DOMINION UNIV,DEPT BIOL SCI,ELECTRON MICROSCOPY LAB,NORFOLK,VA 23508

来源：

ANNALS OF NEUROLOGY | 1992年 / 31卷 / 05期

关键词：

D O I：

10.1002/ana.410310517

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Vessels affected by amyloid angiopathy in patients with Alzheimer's disease also displayed intense acetylcholinesterase and butyrylcholinesterase activity when examined by light and electron microscopy. The enzymatic properties of the vessel-bound cholinesterases were identical to those of the cholinesterases associated with senile plaques and neurofibrillary tangles. This cholinesterase activity is of unknown origin but represents one of the very few features common to all the major pathological markers of Alzheimer's disease.

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页码：565 / 569

页数：5

相关论文

共 14 条

[1] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].

ABRAHAM, CR ;

SELKOE, DJ ;

POTTER, H .

CELL, 1988, 52 (04) :487-501

[2] ELECTRON-MICROSCOPIC LOCALIZATION OF CHOLINESTERASE ACTIVITY IN ALZHEIMER BRAIN-TISSUE [J].

CARSON, KA ;

GEULA, C ;

MESULAM, MM .

BRAIN RESEARCH, 1991, 540 (1-2) :204-208

[3] PEPTIDASIC ACTIVITIES ASSOCIATED WITH ACETYLCHOLINESTERASE ARE DUE TO CONTAMINATING ENZYMES [J].

CHECLER, F ;

VINCENT, JP .

JOURNAL OF NEUROCHEMISTRY, 1989, 53 (03) :924-928

[4] A4 AMYLOID PROTEIN DEPOSITION AND THE DIAGNOSIS OF ALZHEIMERS-DISEASE - PREVALENCE IN AGED BRAINS DETERMINED BY IMMUNOCYTOCHEMISTRY COMPARED WITH CONVENTIONAL NEUROPATHOLOGIC TECHNIQUES [J].

DAVIES, L ;

WOLSKA, B ;

HILBICH, C ;

MULTHAUP, G ;

MARTINS, R ;

SIMMS, G ;

BEYREUTHER, K ;

MASTERS, CL .

NEUROLOGY, 1988, 38 (11) :1688-1693

[5] SPECIAL PROPERTIES OF CHOLINESTERASES IN THE CEREBRAL-CORTEX OF ALZHEIMERS-DISEASE [J].

GEULA, C ;

MESULAM, M .

BRAIN RESEARCH, 1989, 498 (01) :185-189

[6] CORTICAL CHOLINERGIC FIBERS IN AGING AND ALZHEIMERS-DISEASE - A MORPHOMETRIC STUDY [J].

GEULA, C ;

MESULAM, MM .

NEUROSCIENCE, 1989, 33 (03) :469-481

[7] CLINICALLY DIAGNOSED ALZHEIMERS-DISEASE - AUTOPSY RESULTS IN 150 CASES [J].

JOACHIM, CL ;

MORRIS, JH ;

SELKOE, DJ .

ANNALS OF NEUROLOGY, 1988, 24 (01) :50-56

[8] SERUM AMYLOID-P IMMUNOREACTIVITY IN HIPPOCAMPAL TANGLES, PLAQUES AND VESSELS - IMPLICATIONS FOR LEAKAGE ACROSS THE BLOOD-BRAIN-BARRIER IN ALZHEIMERS-DISEASE [J].

KALARIA, RN ;

GRAHOVAC, I .

BRAIN RESEARCH, 1990, 516 (02) :349-353

[9] DIAGNOSIS OF ALZHEIMERS-DISEASE [J].

KHACHATURIAN, ZS .

ARCHIVES OF NEUROLOGY, 1985, 42 (11) :1097-1104

[10]

Mesulam M M, 1990, Adv Neurol, V51, P235