A POPULATION OF EARLY FETAL THYMOCYTES EXPRESSING FC-GAMMA-RII/III CONTAINS PRECURSORS OF LYMPHOCYTES-T AND NATURAL-KILLER-CELLS

被引：273

作者：

RODEWALD, HR

MOINGEON, P

LUCICH, JL

DOSIOU, C

LOPEZ, P

REINHERZ, EL

机构：

[1] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, FLOW CYTOMETRY FACIL, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA

[3] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA

来源：

CELL | 1992年 / 69卷 / 01期

关键词：

D O I：

10.1016/0092-8674(92)90125-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified a dominant fetal thymocyte population at day 14.5 of gestation in the mouse that lacks CD4 and CD8 but expresses Fc-gamma-RII/III+ several days prior to acquisition of the T cell receptor (TCR) in vivo. If maintained in a thymic microenvironment, this population of CD4-CD8-TCR-Fc-gamma-RII/III+ thymocytes differentiates first into CD4+CD8+TCR(low)Fc-gamma-RII/III- thymocytes and subsequently CD4+CD8-TCR(high)Fc-gamma-RII/III- and CD4-CD8+TCR(high)Fc-gamma-RII/III mature Ti alpha-beta lineage T cells. However, if removed from the thymus, the CD4-CD8-TCR-Fc-gamma-RII/III+ thymocyte population selectively generates functional natural killer (NK) cells in vivo as well as in vitro. These findings show that a cellular pool of Fc-gamma-RII/III+ precursors gives rise to T and NK lineages in a microenvironment-dependent manner. Moreover, they suggest a hitherto unrecognized role for Fc receptors on primitive T cells.

引用

页码：139 / 150

页数：12

共 97 条

[1] THE HUMAN T-CELL RECEPTOR - APPEARANCE IN ONTOGENY AND BIOCHEMICAL RELATIONSHIP OF ALPHA-SUBUNITS AND BETA-SUBUNITS ON IL-2 DEPENDENT CLONES AND T-CELL TUMORS [J].