NEOSURUGATOXIN BLOCKS AN ALPHA-BUNGAROTOXIN-SENSITIVE NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR

被引：9

作者：

BAI, DL ^{[1
]}

SATTELLE, DB ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT ZOOL,AFRC,MOLEC SIGNALLING LAB,DOWNING ST,CAMBRIDGE CB2 3EJ,ENGLAND

来源：

ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY | 1993年 / 23卷 / 04期

关键词：

IDENTIFIED NEURON; FAST COXAL DEPRESSOR MOTOR NEURON (D(F)); NERVOUS SYSTEM; PERIPLANETA-AMERICANA; CHOLINERGIC PHARMACOLOGY;

D O I：

10.1002/arch.940230403

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neosurugatoxin (NSTX), a neurotoxin isolated from the Japanese ivory mollusc Babylonia japonica, is a potent neuronal nicotinic acetylcholine receptor (nAChR) antagonist. Hitherto, NSTX has been found to block only neuronal nAChRs that are insensitive to alpha-Bgt. Here, we report for the first time that NSTX blocks an alpha-Bgt-sensitive nAChR on an identified insect motor neurone. Bath-applied NSTX at a concentration of 10 nM and above reversibly blocks the nicotine-induced depolarizations recorded from the cockroach (Periplaneta americana) fast coxal depressor motor neurone (D(f)) and is without effect on GABA-induced responses detected on the same cell. NSTX is among the most potent blockers tested to date on nAChRs of motor neurone D(f). (C) 1993 Wiley-Liss, Inc.

引用

页码：161 / 167

页数：7

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