LOCALIZATION OF THE HUMAN STEM-CELL TYROSINE KINASE-1 GENE (FLT3) TO 13Q12-]Q13

被引：27

作者：

CAROW, CE

KIM, E

HAWKINS, AL

WEBB, HD

GRIFFIN, CA

JABS, EW

CIVIN, CI

SMALL, D

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, JOHNS HOPKINS ONCOL CTR, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT MED, BALTIMORE, MD 21205 USA

[3] JOHNS HOPKINS UNIV, SCH MED, DEPT PEDIAT, BALTIMORE, MD 21205 USA

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 70卷 / 3-4期

关键词：

D O I：

10.1159/000134046

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have previously reported the cloning of stem cell tyrosine kinase-l (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34(+) human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12-->q13.

引用

页码：255 / 257

页数：3

共 19 条

[1] DIRECT VISUALIZATION OF SINGLE COPY GENES ON BANDED METAPHASE CHROMOSOMES BY NONISOTOPIC INSITU HYBRIDIZATION [J].