TOCOTRIENOLS FROM PALM OIL AS POTENT INHIBITORS OF LIPID-PEROXIDATION AND PROTEIN OXIDATION IN RAT-BRAIN MITOCHONDRIA

被引:118
作者
KAMAT, JP [1 ]
DEVASAGAYAM, TPA [1 ]
机构
[1] BHABHA ATOM RES CTR, DIV RADIAT BIOL & BIOCHEM, BOMBAY 400085, MAHARASHTRA, INDIA
关键词
BRAIN MITOCHONDRIA; LIPID PEROXIDATION; PROTEIN CARBONYLS; TOCOTRIENOLS; PALM OIL; NATURAL ANTIOXIDANT;
D O I
10.1016/0304-3940(95)11812-B
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The tocotrienol-rich-fraction (TRF) from palm oil, being tried as a more economical and efficient substitute for alpha-tocopherol, significantly inhibited oxidative damage in vitro to both lipids and proteins in rat brain mitochondria induced by ascorbate-Fe2+, the free radical initiator azobis(2-amidopropane)dihydrochloride (AAPH) and photosensitisation. The observed inhibitory effect was both time-and concentration-dependent. At a low concentration of 5 mu M, TRF can significantly inhibit oxidative damage to both lipids and proteins. The inhibitory effect of TRF seems to be mainly due to gamma-tocotrienol and to a lesser extent alpha- and delta-tocotrienols. TRF was significantly more effective than alpha-tocopherol. This fraction from palm oil can be considered a natural antioxidant supplement capable of protecting the brain against oxidative damage and thereby from the ensuing adverse alterations.
引用
收藏
页码:179 / 182
页数:4
相关论文
共 28 条
[1]  
[Anonymous], 1992, LIPID SOLUBLE ANTIOX
[2]  
Buege J A, 1978, Methods Enzymol, V52, P302
[3]   THE PECKING ORDER OF FREE-RADICALS AND ANTIOXIDANTS - LIPID-PEROXIDATION, ALPHA-TOCOPHEROL, AND ASCORBATE [J].
BUETTNER, GR .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 300 (02) :535-543
[4]   DIFFERENCES IN LIPID-PEROXIDATION OF RAT-LIVER ROUGH AND SMOOTH MICROSOMES [J].
DEVASAGAYAM, TPA ;
PUSHPENDRAN, CK ;
EAPEN, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 750 (01) :91-97
[5]   DECREASED PEROXIDATIVE POTENTIAL IN RAT-BRAIN MICROSOMAL FRACTIONS DURING AGING [J].
DEVASAGAYAM, TPA .
NEUROSCIENCE LETTERS, 1989, 103 (01) :92-96
[6]   ROLE OF OXYGEN FREE-RADICALS IN CARCINOGENESIS AND BRAIN ISCHEMIA [J].
FLOYD, RA .
FASEB JOURNAL, 1990, 4 (09) :2587-2597
[7]  
GOSH SH, 1994, INT JCANCER, V57, P529
[8]  
GURR MI, 1992, LIPID TECHNOL APR, P62
[9]  
HALLIWELL B, 1990, METHOD ENZYMOL, V186, P1
[10]  
LISSI E A, 1986, Journal of Free Radicals in Biology and Medicine, V2, P63, DOI 10.1016/0748-5514(86)90125-X