FOLATE ANTAGONISTS .13. 2,4-DIAMINO-6-[ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLYL)THIO]QUINAZOLINE AND RELATED 2,4-DIAMINO-6-[(PHENYL- AND NAPHTHYL)THIO]QUINAZOLINES, A UNIQUE CLASS OF ANTI-METABOLITES WITH EXTRAORDINARY ANTI-MALARIAL AND ANTIBACTERIAL EFFECTS

被引：28

作者：

ELSLAGER, EF ^{[1
]}

JACOB, P ^{[1
]}

JOHNSON, J ^{[1
]}

WERBEL, LM ^{[1
]}

WORTH, DF ^{[1
]}

RANE, L ^{[1
]}

机构：

[1] UNIV MIAMI,SCH MED,MIAMI,FL 33142

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1978年 / 21卷 / 10期

关键词：

D O I：

10.1021/jm00208a010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1059 / 1070

页数：12

共 22 条

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[4] ANTIMALARIAL DRUGS .31. FOLATE ANTAGONIST .9. 2,4-DIAMINO-6-[(ARALKY)ALKYLAMINO] QUINAZOLINES, A POTENT CLASS OF ANTIMETABOLITES WITH PREPRODIGIOUS ANTIMALARIAL EFFECTS
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[5] FOLATE ANTAGONISTS .5. ANTIMALARIAL AND ANTIBACTERIAL EFFECTS OF 2,4-DIAMINO-6-(ARYLOXY AND ARALKOXY)QUINAZOLINE ANTIMETABOLITES
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[6] FOLATE ANTAGONISTS .12. ANTI-MALARIAL AND ANTIBACTERIAL EFFECTS OF 2,4-DIAMINO-6-[(ARALKYL AND ALICYCLIC)THIO SULFINYL]QUINAZOLINES, AND SULFONYL]QUINAZOLINES
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[7] ELSLAGER EF, 1974, 4TH P INT S MED CHEM
[8] HANTZSCH A, 1900, LIEBIGS ANN CHEM, V314, P366
[9] HYNES JB, 1974, J MED CHEM, V17, P682, DOI 10.1021/jm00253a005
[10] Ortho-chlorodinitrotoluenes Part V 2-Chloro-3 6-dinitrotoluene
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