CHARACTERIZATION OF ROS1 CDNA FROM A HUMAN GLIOBLASTOMA CELL-LINE

被引：97

作者：

BIRCHMEIER, C

ONEILL, K

RIGGS, M

WIGLER, M

机构：

[1] COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724

[2] MAX PLANCK GESELL,MAX DELBRUECK LAB,W-5000 COLOGNE 30,GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 12期

关键词：

Oncogenes; Receptors; Sevenless; Tyrosine kinases;

D O I：

10.1073/pnas.87.12.4799

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have isolated and characterized a human ROS1 cDNA from the glioblastoma cell line SW-1088. The cDNA, 8.3 kilobases long, has the potential to encode a transmembrane tyrosine-specific protein kinase with a predicted molecular mass of 259 kDa. The putative extracellular domain of ROS1 is homologous to the extracellular domain of the sevenless gene product from Drosophila. No comparable similarities in the extracellular domains were found between ROS1 and other receptor-type tyrosine kinases. Together, ROS1 and sevenless gene products define a distinct subclass of transmembrane tyrosine kinases.

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页码：4799 / 4803

页数：5

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