AN IMPROVED SYNTHESIS OF SUBSTITUTED BENZO[B]THIOPHEN-2-CARBOXYLIC ACIDS AND RELATED ACIDS

被引:35
作者
CHAKRABA.PM
CHAPMAN, NB
CLARKE, K
机构
[1] Department of Chemistry, The University, Hull
关键词
D O I
10.1016/0040-4020(69)80021-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The oxidative cyclization of β-Aryl-α-mercaptoacrylic acids with chlorine in dry carbon tetrachloride rapidly gives the corresponding benzo[b]thiophen-2-carboxylic acids in high yield. This process is a considerable improvement on processes previously reported. The purity of the crude β-aryl-α-mercaptoacrylic acids can be determined by titration with iodine in ethanol and thus the crude intermediates can be cyclized without further purification by use of the calculated amount of chlorine. © 1969.
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页码:2781 / &
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