LOSS OF NMDA, BUT NOT GABA-A, BINDING IN THE BRAINS OF AGED RATS AND MONKEYS

被引：219

作者：

WENK, GL

WALKER, LC

PRICE, DL

CORK, LC

机构：

[1] JOHNS HOPKINS UNIV,DEPT PSYCHOL,NEUROMNEMON LAB,BALTIMORE,MD 21218

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,NEUROPATHOL LAB,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL & NEUROSCI,NEUROPATHOL LAB,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,DIV COMPARAT MED,BALTIMORE,MD 21205

来源：

NEUROBIOLOGY OF AGING | 1991年 / 12卷 / 02期

关键词：

ACETYLCHOLINE; GLUTAMATE; NMDA; GABA; RECEPTORS; AGING; RATS; MONKEYS;

D O I：

10.1016/0197-4580(91)90047-N

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In this quantitative neurochemical study we investigated age-related changes in the GABAergic, glutamatergic, and cholinergic neurotransmitter systems in rats and rhesus monkeys. Sixteen young (5 months) and 20 aged (24 months) rats and seven "young" (4-9 years), six "adult" (20-25 years), and five "aged" (29-34 years) monkeys were studied. NMDA-displaceable 1-[H-3]glutamate binding was significantly decreased in many neocortical and subcortical regions examined in aged rats and monkeys. The level of choline acetyltransferase (ChAT) activity and [H-3]muscimol binding were unchanged in aged animals.

引用

页码：93 / 98

页数：6

共 68 条

[1] EFFECTS OF SCOPOLAMINE AND PHYSOSTIGMINE ON RECOGNITION MEMORY IN MONKEYS WITH IBOTENIC-ACID LESIONS OF THE NUCLEUS BASALIS OF MEYNERT [J].