DETERMINATION OF N-ACETYLCYSTEINE IN HUMAN PLASMA BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：13

作者：

LONGO, A

DITORO, M

GALIMBERTI, C

CARENZI, A

机构：

[1] Zambon Research S.p.A., Milan, Via Lillo del Duca 10

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 562卷 / 1-2期

关键词：

D O I：

10.1016/0378-4347(91)80614-I

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An automatic mass spectrometric method for the quantitation of N-acetylcysteine (NAC) in human plasma has been developed. NAC was extracted from plasma with ethyl acetate and derivatized in two steps with 2-praponol and pentafluoropropionic anhydride. The volatile derivative obtained was ideal for gas chromatographic-mass spectrometric analysis. Data obtained by analysing the plasma of healthy volunteers to whom 600 mg of NAC had been orally given are reported.

引用

页码：639 / 645

页数：7

共 10 条

[1]

AYLWARD M, 1980, EUR J RESPIR DIS, V61, P81

[2] PHARMACOKINETICS OF N-ACETYLCYSTEINE IN MAN [J].