INHIBITION OF DEGRADATION OF INSULIN BY OPHTHALMIC ACID AND BY A BOVINE PANCREATIC PROTEINASE-INHIBITOR

被引：16

作者：

OFFORD, RE

PHILIPPE, J

DAVIS, JG

HALBAN, PA

BERGER, M

机构：

[1] INST BIOCHIM CLIN,CH-1211 GENEVE 4,SWITZERLAND

[2] DIAB RES INST,D-4000 DUSSELDORF,FED REP GER

[3] UNIV DUSSELDORF,MED KLIN E,D-4000 DUSSELDORF 1,FED REP GER

来源：

BIOCHEMICAL JOURNAL | 1979年 / 182卷 / 01期

关键词：

D O I：

10.1042/bj1820249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously observed that, on subcutaneous administration, a significant proportion of insulin is degraded at the site of injection. The present paper reports that the degradative activity of slices of rat adipose tissue can be inhibited in vitro by ophthalmic acid, a natural analogue of glutathione, and by bovine pancreatic proteinase inhibitor, whereas it is increased by the addition of reduced glutathione.

引用

页码：249 / 251

页数：3

共 17 条

[1] MOBILIZATION OF SUBCUTANEOUSLY INJECTED TRITIATED INSULIN IN RATS - EFFECTS OF MUSCULAR EXERCISE
BERGER, M
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[2] BERGER M, DIABETOLOGIA
[3] MECHANISM OF GLYOXALASE I REACTION, AND EFFECT OF OPHTHALMIC ACID AS AN INHIBITOR
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[4] DAVIES JG, 1978, SEMISYNTHETIC PEPTID, P249
[5] PROTEOLYTIC DEGRADATION OF INSULIN AND GLUCAGON
DUCKWORTH, WC
HEINEMANN, M
KITABCHI, AE
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 377 (02) : 421 - 430
[6] HALBAN P, 1978, DIABETES, V27, P439
[7] DEGRADATION OF SEMISYNTHETIC TRITIATED INSULIN BY PERFUSED MOUSE LIVERS
HALBAN, PA
KARAKASH, C
DAVIES, JG
OFFORD, RE
[J]. BIOCHEMICAL JOURNAL, 1976, 160 (02) : 409 - 412
[8] PREPARATION OF A SEMISYNTHETIC TRITIATED INSULIN WITH A SPECIFIC RADIOACTIVITY OF UP TO 20 CURIES PER MILLIMOLE
HALBAN, PA
OFFORD, RE
[J]. BIOCHEMICAL JOURNAL, 1975, 151 (02) : 219 - 225
[9] HALBAN PA, 1978, SEMISYNTHETIC PEPTID, P237
[10] IZZO JL, 1975, INSULIN, P195

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