MEASUREMENT OF 6-OXO-PGF1-ALPHA IN HUMAN-PLASMA USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY

被引：70

作者：

HENSBY, CN

FITZGERALD, GA

FRIEDMAN, LA

LEWIS, PJ

DOLLERY, CT

机构：

[1] Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London

来源：

PROSTAGLANDINS | 1979年 / 18卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/0090-6980(79)90093-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The plasma concentration of the prostacyclin (PGI2) hydration product 6-oxo-PGF1α has been assayed by stable isotope dilution GC-MS in six normal volunteers infused with increasing doses of PGI2 intravenously. The predosing levels of 6-oxo-PGF1α ranged between 114 and 266 pg/ml. Infusion of PGI2 increased 6-oxo-PGF1α concentration in plasma but the increments were lower than expected suggesting less conversion of the PGI2 to 6-oxo-PGF1α at high infusion rates. © 1979.

引用

页码：731 / 736

页数：6

共 10 条

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