PERISTALSIS EVOKED BY 5-HT AND RENZAPRIDE - EVIDENCE FOR PUTATIVE 5-HT4 RECEPTOR ACTIVATION

被引：83

作者：

CRAIG, DA

CLARKE, DE

机构：

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1991年 / 102卷 / 03期

关键词：

D O I：

10.1111/j.1476-5381.1991.tb12211.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of 5-hydroxytryptamine and renzapride was studied on the peristaltic reflex elicited in vitro in the guinea-pig ileum. Both agents evoked the reflex at subthreshold intraluminal pressures (50% of threshold) and were blocked by ICS 205-930 (3-mu-M), but not ondansetron (5-mu-M). This novel finding suggests strongly that the prokinetic action of renzapride and gut motility stimulating action of 5-hydroxytryptamine are mediated via agonism at the putative 5-HT4 receptor.

引用

页码：563 / 564

页数：2

共 8 条

[1] PROPOSALS FOR THE CLASSIFICATION AND NOMENCLATURE OF FUNCTIONAL RECEPTORS FOR 5-HYDROXYTRYPTAMINE
BRADLEY, PB
ENGEL, G
FENIUK, W
FOZARD, JR
HUMPHREY, PPA
MIDDLEMISS, DN
MYLECHARANE, EJ
RICHARDSON, BP
SAXENA, PR
[J]. NEUROPHARMACOLOGY, 1986, 25 (06) : 563 - 576
[2] BULBRING E, 1958, BRIT J PHARM CHEMOTH, V13, P444
[3] CRAIG DA, 1990, J PHARMACOL EXP THER, V252, P1378
[4] CRAIG DA, 1990, N-S ARCH PHARMACOL, V342, P9
[5] KING FD, 1988, ANNU REP MED CHEM, V23, P201
[6] PERIPHERAL NEURAL SEROTONIN RECEPTORS - IDENTIFICATION AND CHARACTERIZATION WITH SPECIFIC ANTAGONISTS AND AGONISTS
MAWE, GM
BRANCHEK, TA
GERSHON, MD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (24) : 9799 - 9803
[7] SCHUURKES JAJ, 1987, CELLULAR PHYSL CLIN, P231
[8] STANIFORTH DH, 1990, EUR J CLIN PHARMACOL, V38, P161

← 1 →