SYNTHESIS OF ALPHA,ALPHA-DIFLUOROKETONES - NOVEL SYNTHESIS OF ALPHA,ALPHA-DIFLUOROKETONES FROM ALPHA,ALPHA-DIFLUOROACYLSILANES

被引：5

作者：

MCCARTHY, PA

WINT, LT

DIAZ, CL

机构：

[1] Department of Medicinal Chemistry, Central Research, Pfizer, Groton, CT 06340, Inc. Eastern Point Road

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80431-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

alpha,alpha-Difluoroketones, targets of interest as potential transition state mimics and enzyme inhibitors, have been synthesized from the corresponding alpha,alpha-difluoroacylsilanes by treatment with diazoalkanes.

引用

页码：119 / 122

页数：4

共 32 条

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