CENTRAL 6-HYDROXYDOPAMINE LESIONS DECREASE MINERALOCORTICOID, BUT NOT GLUCOCORTICOID RECEPTOR GENE-EXPRESSION IN THE RAT HIPPOCAMPUS

被引：31

作者：

YAU, JLW

SECKL, JR

机构：

[1] University of Edinburgh, Department of Medicine, Western General Hospital, Edinburgh

来源：

NEUROSCIENCE LETTERS | 1992年 / 142卷 / 02期

基金：

英国惠康基金;

关键词：

MINERALOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR; HIPPOCAMPUS; MESSENGER RNA; INSITU HYBRIDIZATION; NORADRENERGIC; 6-HYDROXYDOPAMINE;

D O I：

10.1016/0304-3940(92)90363-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of hippocampal noradrenergic inputs in the modulation of corticosteroid receptor expression has been investigated. Adult male rats were given central 6-hydroxydopamine (6-OHDA) and the expression of hippocampal mineralocorticoid (MR) and glucocorticoid (GR) receptor mRNA was examined after two weeks by in situ hybridization histochemistry. Expression of MR mRNA was significantly decreased in all subregions of the hippocampus except CA2, but 6-OHDA lesions had no effect on GR mRNA expression. These data reveal differential regulation of the two receptor types by noradrenergic inputs.

引用

页码：159 / 162

页数：4

共 31 条

[1]

ANGELUCCI L, 1982, TYPICAL ATYPICAL ANT, P365

[2] CLONING OF HUMAN MINERALOCORTICOID RECEPTOR COMPLEMENTARY-DNA - STRUCTURAL AND FUNCTIONAL KINSHIP WITH THE GLUCOCORTICOID RECEPTOR [J].