COMPARATIVE MAPPING OF YRRM-RELATED AND TSPY-RELATED COSMIDS IN MAN AND HOMINOID APES

被引：89

作者：

SCHEMPP, W

BINKELE, A

ARNEMANN, J

GLASER, B

MA, K

TAYLOR, K

TODER, R

WOLFE, J

ZEITLER, S

CHANDLEY, AC

机构：

[1] WESTERN GEN HOSP,MRC,MED ONCOL UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

[2] UNIV FRANKFURT,INST HUMAN GENET,W-6000 FRANKFURT,GERMANY

[3] UNIV LONDON UNIV COLL,GALTON LAB,LONDON NW1 2HE,ENGLAND

来源：

CHROMOSOME RESEARCH | 1995年 / 3卷 / 04期

关键词：

HOMINOIDS; SPERMATOGENESIS GENES; Y-CHROMOSOME EVOLUTION;

D O I：

10.1007/BF00713047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using chromosomal in situ hybridization it has been demonstrated that specific members of the YRRM and the TSPY families are multicopy and Y chromosome specific in hominoids. After hybridization with the YRRM-related cosmid A5F and the TSPY-related cosmids cos36 and cY91, a reverse and complementary pattern of main and secondary signals is detected on the Y chromosomes of the human, the pygmy chimpanzee and the gorilla, while the location of signals coincides on the Y chromosomes of the chimpanzee, both orang-utan subspecies and the white hand gibbon. This complementary distribution of YRRM and TSPY sequences on the hominoid Y chromosomes possibly originates from a similar sequence motif that is shared by and evolutionarily conserved between certain members of both gene families and/or repeated elements flanking those genes. Otherwise this complementary distribution could go back to a common organization of these genes next to each other on an ancient Y chromosome which was disrupted by chromosomal rearrangements and amplification of one or other of the genes at each of the locations.

引用

页码：227 / 234

页数：8

共 32 条

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