COMPARATIVE MAPPING OF YRRM-RELATED AND TSPY-RELATED COSMIDS IN MAN AND HOMINOID APES

被引:89
作者
SCHEMPP, W
BINKELE, A
ARNEMANN, J
GLASER, B
MA, K
TAYLOR, K
TODER, R
WOLFE, J
ZEITLER, S
CHANDLEY, AC
机构
[1] WESTERN GEN HOSP,MRC,MED ONCOL UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND
[2] UNIV FRANKFURT,INST HUMAN GENET,W-6000 FRANKFURT,GERMANY
[3] UNIV LONDON UNIV COLL,GALTON LAB,LONDON NW1 2HE,ENGLAND
关键词
HOMINOIDS; SPERMATOGENESIS GENES; Y-CHROMOSOME EVOLUTION;
D O I
10.1007/BF00713047
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Using chromosomal in situ hybridization it has been demonstrated that specific members of the YRRM and the TSPY families are multicopy and Y chromosome specific in hominoids. After hybridization with the YRRM-related cosmid A5F and the TSPY-related cosmids cos36 and cY91, a reverse and complementary pattern of main and secondary signals is detected on the Y chromosomes of the human, the pygmy chimpanzee and the gorilla, while the location of signals coincides on the Y chromosomes of the chimpanzee, both orang-utan subspecies and the white hand gibbon. This complementary distribution of YRRM and TSPY sequences on the hominoid Y chromosomes possibly originates from a similar sequence motif that is shared by and evolutionarily conserved between certain members of both gene families and/or repeated elements flanking those genes. Otherwise this complementary distribution could go back to a common organization of these genes next to each other on an ancient Y chromosome which was disrupted by chromosomal rearrangements and amplification of one or other of the genes at each of the locations.
引用
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页码:227 / 234
页数:8
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