HEAT-SHOCK PROTEINS AND AUTOIMMUNITY - A CRITICAL-APPRAISAL

被引：34

作者：

KAUFMANN, SHE

机构：

[1] Department of Immunology, University of Ulm

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 103卷 / 04期

关键词：

AUTOIMMUNE DISEASE; HEAT SHOCK PROTEINS; INFECTION; ORAL TOLERANCE; PEPTIDE THERAPY;

D O I：

10.1159/000236648

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Various lines of evidence suggest a close relationship between heat shock proteins (hsp) and numerous autoimmune diseases. However, the common interpretation of hsp as antigens which provide a direct link between infection and autoimmunity appears insufficient. Rather, anti-hsp immune responses seem to represent physiological constituents of immune homeostasis. hsp are found in different sources, including infectious agents, nutriment and self, and the development of autoimmune disease seems to be related to an imbalanced presentation of hsp peptides to the immune system from these different sources.

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页码：317 / 322

页数：6

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