CYSTEINE AND METHIONINE LINKED BY CARBON PSEUDOPEPTIDES INHIBIT FARNESYL TRANSFERASE

被引：14

作者：

HARRINGTON, EM ^{[1
]}

KOWALCZYK, JJ ^{[1
]}

PINNOW, SL ^{[1
]}

ACKERMANN, K ^{[1
]}

GARCIA, AM ^{[1
]}

LEWIS, MD ^{[1
]}

机构：

[1] EISAI RES INST,ANDOVER,MA 01810

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(01)80593-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Compounds in which cysteine and methionine have been linked by amino acids replacing the A(1)A(2) portion of the CA(1)A(2)X box template inhibit farnesyl and geranylgeranyl transferases. The expected specificity for FTase over GGTase I is observed. A variety of linkers are accepted with the most potent compounds possessing a hydrophobic substituent at C-2 of the A(1)A(2) replacement.

引用

页码：2775 / 2780

页数：6

共 30 条

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