THE INSITU CHEMICAL-ANALYSIS OF POLYMER FILM COATINGS USING STATIC SECONDARY ION MASS-SPECTROMETRY (SSIMS)

被引：4

作者：

DAVIES, MC ^{[1
]}

WILDING, IR ^{[1
]}

SHORT, RD ^{[1
]}

MELIA, CD ^{[1
]}

ROWE, RC ^{[1
]}

机构：

[1] ICI PHARMACEUT PLC,MACCLESFIELD SK10 2TG,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 62卷 / 2-3期

关键词：

Cellulose ester; Cellulose ether; Chemical analysis; in situ; Poly(methacrylate) copolymer; Polymer film coating; Static secondary ion mass spectrometry;

D O I：

10.1016/0378-5173(90)90222-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The SSIMS (static secondary ion mass spectrometry) analysis of a range of cellulose ethers, esters and poly(methacrylate) copolymers used as film coating agents in the pharmaceutical industry is described. Certain ions generated in the positive and/or negative SSIMS spectra appear to be characteristic of the particular polymer investigated, reflecting both the monomeric composition of the backbone chain and in particular the side-group substituents that are present. As a result, it appears that SSIMS is capable of positively identifying different film coating polymers when cast as films. © 1990.

引用

页码：97 / 103

页数：7

共 14 条

[1]

BRIGGS D, 1986, SURF INTERFACE ANAL, V9, P391

[2] INTERACTION OF ION-BEAMS WITH POLYMERS, WITH PARTICULAR REFERENCE TO SIMS [J].