THE INSITU CHEMICAL-ANALYSIS OF POLYMER FILM COATINGS USING STATIC SECONDARY ION MASS-SPECTROMETRY (SSIMS)

被引:4
作者
DAVIES, MC [1 ]
WILDING, IR [1 ]
SHORT, RD [1 ]
MELIA, CD [1 ]
ROWE, RC [1 ]
机构
[1] ICI PHARMACEUT PLC,MACCLESFIELD SK10 2TG,ENGLAND
关键词
Cellulose ester; Cellulose ether; Chemical analysis; in situ; Poly(methacrylate) copolymer; Polymer film coating; Static secondary ion mass spectrometry;
D O I
10.1016/0378-5173(90)90222-P
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The SSIMS (static secondary ion mass spectrometry) analysis of a range of cellulose ethers, esters and poly(methacrylate) copolymers used as film coating agents in the pharmaceutical industry is described. Certain ions generated in the positive and/or negative SSIMS spectra appear to be characteristic of the particular polymer investigated, reflecting both the monomeric composition of the backbone chain and in particular the side-group substituents that are present. As a result, it appears that SSIMS is capable of positively identifying different film coating polymers when cast as films. © 1990.
引用
收藏
页码:97 / 103
页数:7
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