COMPARISON OF 15 MONOCLONAL-ANTIBODIES AGAINST TUMOR-ASSOCIATED ANTIGENS OF TRANSITIONAL CELL-CARCINOMA OF THE HUMAN BLADDER

被引:23
作者
HULAND, E
MEIER, T
BARICORDI, O
FRADET, Y
GROSSMAN, HB
HODGES, GM
MESSING, EM
SCHMITZDRAEGER, BJ
机构
[1] UNIV LAVAL,QUEBEC CITY G1K 7P4,QUEBEC,CANADA
[2] UNIV MICHIGAN,ANN ARBOR,MI 48109
[3] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND
[4] UNIV WISCONSIN,MADISON,WI 53706
[5] UNIV DUSSELDORF,W-4000 DUSSELDORF 1,GERMANY
[6] UNIV FERRARA,I-44100 FERRARA,ITALY
关键词
BLADDER NEOPLASMS; ANTIBODIES; MONOCLONAL; MARKERS; TUMOR; CYTOLOGICAL TECHNIQUES;
D O I
10.1016/S0022-5347(17)38202-2
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Quantitative urinary immunocytology with our monoclonal antibody (mab) 486p 3/12 proved to be valuable for diagnostic use in bladder-cancer patients' urine, especially in the followup of patients with superficial bladder carcinoma. To evaluate the use of other monoclonal antibodies in bladder cancer, we compared 15 mabs directed against bladder-tumor-associated antigens from seven research groups in a broad panel of cellular and tissue specimens (bladder tumor, prostatic adenoma, and kidney stone). Quantitative evaluation was done in cytocentrifuged preparations and tissue specimens. None of the 15 mabs was bladder-tumor-specific. All 15 stained normal urothelium to some extent and six stained granulocytes. Each of the 15 seemed to identify a different cellular antigen, as can be clearly demonstrated by the staining pattern of different regions in the normal kidney. The sensitivity of quantitative urinary immunocytology in bladder-tumor patients can be improved by using a panel, rather than one mab in bladder-tumor patients, but specificity decreases simultaneously. A main reason for the poor specificity of quantitative urinary immunocytology with all 15 mabs is that false-positive results are obtained with all mabs in kidney-stone patients. Our quantitative urinary immunocytology method is a general tool for the diagnostic use of all mabs in bladder-tumor patients. Mabs that have a high sensitivity might be useful in the followup of patients with superficial bladder carcinoma. None of the 15 mabs (because of their poor specificity) seems to be helpful in quantitative urinary immunocytology for screening a population for bladder carcinoma.
引用
收藏
页码:1631 / 1636
页数:6
相关论文
共 13 条
[1]   MONOCLONAL-ANTIBODIES FOR CHARACTERIZATION OF THE HETEROGENEITY OF NORMAL AND MALIGNANT TRANSITIONAL CELLS [J].
ARNDT, R ;
DURKOPF, H ;
HULAND, H ;
DONN, F ;
LOENING, T ;
KALTHOFF, H .
JOURNAL OF UROLOGY, 1987, 137 (04) :758-763
[2]   A MONOCLONAL-ANTIBODY TO HUMAN TRANSITIONAL-CELL CARCINOMA OF THE BLADDER CROSS-REACTING WITH A DIFFERENTIATION ANTIGEN OF NEUTROPHILIC LINEAGE [J].
BARICORDI, OR ;
SENSI, A ;
DEVINCI, C ;
MELCHIORRI, L ;
FABRIS, G ;
MARCHETTI, E ;
CORRADO, F ;
MATTIUZ, PL ;
PIZZA, G .
INTERNATIONAL JOURNAL OF CANCER, 1985, 35 (06) :781-786
[3]   POLYMORPHIC EXPRESSION OF A HUMAN SUPERFICIAL BLADDER-TUMOR ANTIGEN DEFINED BY MOUSE MONOCLONAL-ANTIBODIES [J].
FRADET, Y ;
ISLAM, N ;
BOUCHER, L ;
PARENTVAUGEOIS, C ;
TARDIF, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7227-7231
[4]   CELL-SURFACE ANTIGENS OF HUMAN BLADDER-CANCER DEFINED BY MOUSE MONOCLONAL-ANTIBODIES [J].
FRADET, Y ;
CORDONCARDO, C ;
THOMSON, T ;
DALY, ME ;
WHITMORE, WF ;
LLOYD, KO ;
MELAMED, MR ;
OLD, LJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (01) :224-228
[5]   DIAGNOSIS OF SUPERFICIAL BLADDER-CARCINOMA WITH URINARY CYTOLOGY, IMMUNE CYTOLOGY AND FLOW-CYTOMETRY - RESULTS OF A PROSPECTIVE-STUDY [J].
HULAND, E ;
HULAND, H ;
ARNDT, R ;
BAISCH, H ;
KLOPPEL, G .
AKTUELLE UROLOGIE, 1988, 19 (01) :13-17
[6]   MONOCLONAL-ANTIBODY 486-P-3/12 - A VALUABLE BLADDER-CARCINOMA MARKER FOR IMMUNOCYTOLOGY [J].
HULAND, H ;
ARNDT, R ;
HULAND, E ;
LOENING, T ;
STEFFENS, M .
JOURNAL OF UROLOGY, 1987, 137 (04) :654-659
[7]  
HULAND H, IN PRESS J UROL
[8]  
KLAN R, 1991, IN PRESS J UROL, V145
[9]  
LIEBERT M, 1989, CANCER RES, V49, P6720
[10]   MURINE HYBRIDOMA ANTIBODIES AGAINST HUMAN TRANSITIONAL CARCINOMA-ASSOCIATED ANTIGENS [J].
MESSING, EM ;
BUBBERS, JE ;
WHITMORE, KE ;
DEKERNION, JB ;
NESTOR, MS ;
FAHEY, JL .
JOURNAL OF UROLOGY, 1984, 132 (01) :167-172